Prepare Stove-Top Macaroni and Cheese as directed; cool slightly. Meanwhile, preheat oven to 400 degrees F. Coat a 2-quart rectangular baking dish with cooking spray; set aside.
In a small saucepan combine maple syrup, mustard, vinegar, thyme, and salt. Bring to boiling, stirring constantly; reduce heat. Boil gently, uncovered, about 4 minutes or until slightly thickened, stirring occasionally. Remove from heat. In a small bowl combine panko and melted butter, stirring to coat evenly.
Spread 2 cups of the macaroni and cheese in the prepared baking dish. For each ham roll, lay two slices of ham next to each other, overlapping slightly. Place 1/4 cup of the remaining macaroni and cheese in the center of one ham slice. Roll ham slices around filling and place on top of macaroni and cheese in dish.
Pour syrup mixture over ham rolls; sprinkle with crumb topping. Bake, uncovered, about 20 minutes or until mixture is heated through and crumbs are golden.