They may be one of the newer wrinkle fighters on the block, but "they're quite effective at stimulating skin-plumping collagen production," says New York City dermatologist Debra Jaliman, M.D. And science agrees -- one study, published in the Journal of Drugs in Dermatology, found that 83 percent of women between ages 35 and 65 who tried creams (like Peter Thomas Roth FirmX Growth Factor Extreme Neuropeptide Serum, $150) containing growth factors found improvement in their wrinkles after 60 days.
Dermatologists aren't shy about their love of lasers. One of Dr. Jaliman's favorites is the Laser Genesis, which uses heat below the surface of the skin to stimulate collagen, smooth lines, and shrink pore size. "It usually takes a series of three to six treatments done two weeks apart to see the full effect," Dr. Jaliman says.
Looking for the perfect product combo? At night, pair a retinol cream (like Philosophy Help Me Retinol Night Treatment, $45) with an antioxidant serum (like Juice Beauty Antioxidant Serum, $45). "This provides a 'reservoir effect,' that helps your skin recover and repair itself while you sleep," says Ava Shamban, M.D., a dermatologist in Santa Monica.
By now, using a broad spectrum SPF (we like Clinique Broad Spectrum Sunscreen SPF 50, $21) to prevent sunburn and premature aging should be a no-brainer. But if you need a reminder: "The sun causes the breakdown of collagen, elastin, and other substances in the skin which leads to wrinkling," says Susan Taylor, M.D., a dermatologist in Philadelphia. "Block the sun and you prevent wrinkles. Period."
Nutrient-rich avocado penetrates deep beneath the surface layer of the skin for intense therapy, helping moisturize skin and calm any kind of inflammation. To make an avocado mask, Ludmila Milic from Lorien Spa in Alexandria, Virginia, suggests mashing a whole avocado with 1 tablespoon of honey. Apply the mask to your face with your fingers and let it sit for 10 minutes before rinsing off with tepid water.
Injectable neurotoxins like Botox Cosmetic, Dysport, and Xeomin freeze targeted muscles in the face to smooth wrinkles caused by over-expression and sun exposure (think: between eyebrows, in the crow's feet area around the eyes, and on the forehead). "You want to look well-rested, not obviously frozen," says Robert Grant, M.D., a New York City plastic surgeon. Bottom line: Go to an experienced injector for best results.