Dermatologists' Favorite Drugstore Wrinkle Fighters

Infused with a hefty dose of retinol, this serum tackles crow's feet, fine lines, and wrinkles. "You'll start to see them start to soften in about week," says Debra Jaliman, M.D., a dermatologist and author of Skin Rules. "This serum also contains hyaluronic acid, which helps prevent the dryness caused by other products that contain retinol." 

This DIY microdermabrasion kit scores bonus points for having undergone clinical trials, proving it’s safe for at-home use. “It's remarkable how smooth and soft it makes the skin feel without leaving it stripped or over-exfoliated,” adds Doris Day, M.D., clinical associate professor of dermatology at the New York University Langone Medical Center. Bonus: Removing that layer of dead, dull cells will help your wrinkle-fighting serums and creams penetrate the skin, improving their effectiveness.

Ask any dermatologist and they’ll tell you that the real fountain of youth can be found in a bottle of sunscreen. Jeanine Downie, a dermatologist in Montclair, New Jersey, is loyal to this hypoallergenic pick because it’s less likely to irritate. Plus, “wearing sunblock rain or shine decreases your incidence of skin cancer, and you’ll have fewer sunspots, fine lines, and moles,” she says.

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Good ingredients are what make a drugstore product powerful, says Ranella Hirsch, M.D., a Cambridge, Massachusetts dermatologist. Hyaluronic acid, a potent moisturizer that is absorbed easily by the skin, and lipohydroxy acid, a gentle exfoliating ingredient, team up in this serum to stimulate collagen, smooth wrinkles, and plump skin.