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1. Preheat oven to 350 degrees F. Coat a 2-quart rectangular or square baking dish with cooking spray; set aside. Cook pasta according to package directions; drain and set aside.
2. Coat a large nonstick skillet with cooking spray; heat over medium heat. Add turkey, sweet pepper, and onion to hot skillet; cook for 6 to 8 minutes or until turkey is no longer pink, stirring occasionally. Transfer turkey mixture to a large bowl. Stir in drained pasta, the spinach, and artichoke hearts. Add Alfredo sauce and cheese, stirring to coat all ingredients. Spoon evenly into the prepared baking dish.
3. Bake for 15 minutes. Stir casserole and spread into an even layer. Sprinkle with panko. Lightly coat panko with cooking spray. Bake for 10 to 15 minutes more or until heated through and panko is lightly browned. Let stand for 15 minutes before serving.