Hi, Well if you have a small crop of potatoes, the easiest way to combat them is to hand pick them and kill them. However, if you want to spray, I'd recommend going organic first. There are products such as Neem and Pyola that will help keep these beetles under control. You can find a wide range of organic products available from Gardens Alive! at www.gardensalive.com. Or, you can use a spray insecticide that lists potato beetles on the label. That would be my last option.