There's no real easy way to get rid of them except with persistence. If Round up isn't working well, I'd switch to something a bit stronger like a brush killer. Cut your saplings down to ground level and immediately apply brush killer to the exposed surfaces. Look for a brush killer that will work for trees and if sumac is listed on the label, that's even better. You can buy brush killers at Home Depot, Lowe's, Wal-Mart or independent garden centers.
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